Maged1 (基因名), Melanoma-associated antigen D1 (蛋白名), magd1_mouse.
产品名称:
Mouse Maged1/ Melanoma-associated antigen D1 CLIA Kit
与黑素瘤相关抗原D1
货号:
U6073m
商标:
EIAab®
监管等级:
别名:
Dlxin-1, MAGE-D1 antigen, Neurotrophin receptor-interacting MAGE homolog, Nrage
检测方法:
CLIA
特异性:
Natural and recombinant mouse Melanoma-associated antigen D1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
功能:
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
亚细胞位置:
Nucleus
Cytoplasm
Cell membrane
Peripheral membrane protein
Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
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