MAML2 (基因名), Mastermind-like protein 2 (蛋白名), maml2_human.
通用注释
亚单元:
Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa.
功能:
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
亚细胞位置:
Nucleus speckle
Nuclear, in a punctate manner.
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