Mad1l1 (基因名), Mitotic spindle assembly checkpoint protein MAD1 (蛋白名), md1l1_mouse.
产品名称:
Mouse Mad1l1/ Mitotic spindle assembly checkpoint protein MAD1 CLIA Kit
有丝分裂纺锤体装配检查点蛋白MAD1
货号:
U5695m
商标:
EIAab®
监管等级:
别名:
Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mad1
检测方法:
CLIA
特异性:
Natural and recombinant mouse Mitotic spindle assembly checkpoint protein MAD1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex (By similarity). Interacts with NEK2. Interacts with TPR; the interactions occurs in a microtubule-independent manner.
功能:
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
亚细胞位置:
Nucleus
Chromosome
Centromere
Kinetochore
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore (By similarity).
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