ABCB1 (基因名), ATP-dependent translocase ABCB1 (蛋白名), mdr1_human.
产品名称:
Human ABCB1/ ATP-dependent translocase ABCB1 CLIA Kit
多药耐药蛋白1
货号:
U8039h
商标:
EIAab®
监管等级:
别名:
ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, Phospholipid transporter ABCB1, CD243, MDR1, PGY1
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
19.5-1250pg/mL
特异性:
Natural and recombinant human ATP-dependent translocase ABCB1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Signal Transduction
通用注释
亚单元:
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
功能:
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Apical cell membrane
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