ABCB4 (基因名), Phosphatidylcholine translocator ABCB4 (蛋白名), mdr3_human.
产品名称:
Human ABCB4/ Phosphatidylcholine translocator ABCB4 CLIA Kit
多药耐药蛋白3
货号:
U10409h
商标:
EIAab®
监管等级:
别名:
ATP-binding cassette sub-family B member 4, Multidrug resistance protein 3, P-glycoprotein 3, MDR3, PGY3
检测方法:
CLIA
特异性:
Natural and recombinant human Phosphatidylcholine translocator ABCB4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cardiovascular
通用注释
亚单元:
May interact with RACK1 (PubMed:19674157). Interacts with HAX1.
功能:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Apical cell membrane
Multi-pass membrane protein
Membrane raft
Cytoplasm
Cytoplasmic vesicle
Clathrin-coated vesicle
Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity). Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed:19674157). Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (PubMed:15258199). Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132).
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