Human MITF/ Microphthalmia-associated transcription factor CLIA Kit
Microphthalmia-associated转录因子

货号:

U0547h

商标:

EIAab^®

监管等级:

RUO

别名:

Class E basic helix-loop-helix protein 32, bHLHe32, BHLHE32

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

78-5000pg/mL

特异性:

Natural and recombinant human Microphthalmia-associated transcription factor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

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Human MITF CLIA Kit

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产品说明书

说明书:

MSDS:

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数据
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通用注释

亚单元:

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC. Interacts with KARS. Identified in a complex with HINT1 and CTNNB1.

功能:

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.166017

SMR:

O75030

STRING:

9606.ENSP00000295600

KEGG:

hsa:4286

MIM: