MAPK1 (基因名), Mitogen-activated protein kinase 1 (蛋白名), mk01_human.
产品名称:
Human MAPK1/ Mitogen-activated protein kinase 1 CLIA Kit
促分裂原激活蛋白激酶1
货号:
U1206h
商标:
EIAab®
监管等级:
别名:
ERT1, Extracellular signal-regulated kinase 2, MAP kinase isoform p42, Mitogen-activated protein kinase 2, ERK-2, p42-MAPK, MAP kinase 2, MAP kinase 1, ERK2, PRKM1, PRKM2
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
19.5-1250pg/mL
特异性:
Natural and recombinant human Mitogen-activated protein kinase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Binds both upstream activators and downstream substrates in multimolecular complexes. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The phosphorylated form interacts with PML (isoform PML-4). Interacts with STYX. Interacts with CDK2AP2.
功能:
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
亚细胞位置:
Cytoplasm
Cytoskeleton
Spindle
Nucleus
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Cytoplasm
Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization.
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