MAP1LC3A (基因名), Microtubule-associated proteins 1A/1B light chain 3A (蛋白名), mlp3a_human.
产品名称:
Human MAP1LC3A/ Microtubule-associated proteins 1A/1B light chain 3A CLIA Kit
HumanMicrotubule-associatedproteins1A/1Blightchain3A
货号:
U2879h
商标:
EIAab®
监管等级:
别名:
Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, MAP1 light chain 3-like protein 1, MAP1A/MAP1B light chain 3 A, Microtubule-associated protein 1 light chain 3 alpha, MAP1A/MAP1B LC3 A
检测方法:
CLIA
特异性:
Natural and recombinant human Microtubule-associated proteins 1A/1B light chain 3A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2 (PubMed:19056683, PubMed:22470510). Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (PubMed:17580304). Interacts with ATG13 (PubMed:24290141, PubMed:23043107). Interacts with ULK1 (PubMed:23043107). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV (PubMed:26347139). Interacts with FAM134A, FAM134B and FAM134C (PubMed:26040720).
功能:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).
亚细胞位置:
Cytoplasm
Cytoskeleton
Endomembrane system
Lipid-anchor
Cytoplasmic vesicle
Autophagosome membrane
Lipid-anchor
Cytoplasmic vesicle
Autophagosome
LC3-II binds to the autophagic membranes.
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