Map2k1 (基因名), Dual specificity mitogen-activated protein kinase kinase 1 (蛋白名), mp2k1_rat.
产品名称:
Rat Map2k1/ Dual specificity mitogen-activated protein kinase kinase 1 CLIA Kit
双重特异性促分裂原活化蛋白激酶激酶1
货号:
U10995r
商标:
EIAab®
监管等级:
别名:
ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1, MAP kinase kinase 1, Mek1, Prkmk1
检测方法:
CLIA
特异性:
Natural and recombinant rat Dual specificity mitogen-activated protein kinase kinase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Forms a heterodimer with MAP2K2/MEK2. Forms heterodimers with KSR2 which further dimerize to form tetramers. Interacts with MORG1 and VRK2. Interacts with SGK1, BIRC6/bruce and KSR1 (By similarity). Found in a complex with at least BRAF, HRAS, MAPK3/ERK1 and RGS14 (PubMed:19319189). Interacts with ARRB2, LAMTOR3, MAPK1/ERK2, and RAF1 (via the proline-rich domain) (PubMed:7565670, PubMed:9733512, PubMed:11226259, PubMed:14993270).
功能:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
亚细胞位置:
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Cytoplasm
Cytoskeleton
Microtubule organizing center
Spindle pole body
Cytoplasm
Nucleus
Membrane
Peripheral membrane protein
Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis. Membrane localization is probably regulated by its interaction with KSR1.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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