首页 > 化学发光试剂盒 > Human MAP2K7 CLIA Kit

MAP2K7 (基因名), Dual specificity mitogen-activated protein kinase kinase 7 (蛋白名), mp2k7_human.

产品名称:

Human MAP2K7/ Dual specificity mitogen-activated protein kinase kinase 7 CLIA Kit
双特异性分裂素激活蛋白激酶7

货号:

U15099h

商标:

EIAab^®

监管等级:

RUO

别名:

JNK-activating kinase 2, MAPK/ERK kinase 7, Stress-activated protein kinase kinase 4, c-Jun N-terminal kinase kinase 2, MEK 7, SAPK kinase 4, JNK kinase 2, MAP kinase kinase 7, JNKK2, MEK7, MKK7, PRKMK7, SKK4

检测方法:

CLIA

特异性:

Natural and recombinant human Dual specificity mitogen-activated protein kinase kinase 7

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

关注

Human MAP2K7 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.

功能:

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

亚细胞位置:

Nucleus Cytoplasm

数据库链接

UniGene:

Hs.531754

SMR:

O14733

STRING:

9606.ENSP00000381066

KEGG:

hsa:5609

MIM: