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MUC4 (基因名), Mucin-4 (蛋白名), muc4_human.

产品名称:

Human MUC4/ Mucin-4 CLIA Kit
Mucin-4

货号:

U1034h

商标:

EIAab^®

监管等级:

RUO

别名:

Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, ASGP, MUC-4

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Mucin-4

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.

功能:

May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

亚细胞位置:

Isoform 17 Cell membrane Single-pass membrane protein

数据库链接

UniGene:

Hs.369646

SMR:

Q99102

STRING:

9606.ENSP00000417498

KEGG:

hsa:4585

MIM:

158372

Pfam:

PF06119

Uniprot:

Q99102

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序列长度:

2169

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仅供参考，详细请咨询（services@eiaab.com）

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WGCSGARFSY | FLNSAEALP

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Human MUC4/ Mucin-4 CLIA Kit Mucin-4

U1034h

Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, ASGP, MUC-4

Human MUC4/ Mucin-4 CLIA Kit
Mucin-4