Rat Nacc1/ Nucleus accumbens-associated protein 1 CLIA Kit

货号:

U2524r

商标:

EIAab^®

监管等级:

RUO

别名:

BTB/POZ domain-containing protein 14B, NAC-1, Btbd14b, Nac1

检测方法:

CLIA

特异性:

Natural and recombinant rat Nucleus accumbens-associated protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Nacc1 CLIA Kit

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通用注释

亚单元:

Homooligomer; mediated by the BTB domain (By similarity). Both isoforms interact with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1.

功能:

Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

亚细胞位置:

Nucleus Cytoplasm Punctate distribution in nucleus. In differentiated PC12 cells diffusely distributed in the cytoplasm and is dependent on phosphorylation.

数据库链接

UniGene:

Rn.108186

SMR:

O35260

STRING:

10116.ENSRNOP00000003884

KEGG:

rno:171454

Pfam:

PF10523

Uniprot: