Rat Ncor1/ Nuclear receptor corepressor 1 CLIA Kit
核受体辅抑制因子1

货号:

U0349r

商标:

EIAab^®

监管等级:

RUO

别名:

N-CoR

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

4.69-300pg/mL

特异性:

Natural and recombinant rat Nuclear receptor corepressor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Rat Ncor1 CLIA Kit

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产品说明书

说明书:

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通用注释

亚单元:

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA.

功能:

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Rn.24948

Uniprot:

Q9WUB5

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