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NCOR2 (基因名), Nuclear receptor corepressor 2 (蛋白名), ncor2_human.

产品名称:

Human NCOR2/ Nuclear receptor corepressor 2 CLIA Kit
核受体辅抑制因子2

货号:

U0334h

商标:

EIAab^®

监管等级:

RUO

别名:

CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, Thyroid-, retinoic-acid-receptor-associated corepressor, SMRT, TRAC, N-CoR2, CTG26

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

15.6-1000pg/mL

特异性:

Natural and recombinant human Nuclear receptor corepressor 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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Human NCOR2 CLIA Kit

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通用注释

亚单元:

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2.

功能:

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.137510

SMR:

Q9Y618

STRING:

9606.ENSP00000384018

KEGG:

hsa:9612

MIM:

600848

Pfam:

PF15784

Uniprot:

Q9Y618

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Mouse Ncor2 Monoclonal Antibody

序列长度:

2525

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GPHHAWDEEP | KPLLCSQYET | LSDSE

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Human NCOR2/ Nuclear receptor corepressor 2 CLIA Kit 核受体辅抑制因子2

U0334h

CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, T3 receptor-associating factor, Thyroid-, retinoic-acid-receptor-associated corepressor, SMRT, TRAC, N-CoR2, CTG26

Human NCOR2/ Nuclear receptor corepressor 2 CLIA Kit
核受体辅抑制因子2