NDN (基因名), Necdin (蛋白名), necd_human.
通用注释
亚单元:
Binds to the transactivation domains of E2F1 and p53. Binds also SV40 large T antigen and adenovirus E1A. Interacts with nucleobindin 1 and 2.
功能:
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.
亚细胞位置:
Perikaryon
Nucleus
Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
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