KLRK1 (基因名), NKG2-D type II integral membrane protein (蛋白名), nkg2d_pig.
产品名称:
Pig KLRK1/ NKG2-D type II integral membrane protein CLIA Kit
货号:
U9376p
商标:
EIAab®
监管等级:
别名:
Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CD314, NKG2D
检测方法:
CLIA
特异性:
Natural and recombinant pig NKG2-D type II integral membrane protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
-
通用注释
亚单元:
Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Can form disulfide-bonded heterodimer with CD94 (By similarity). Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1.
功能:
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
亚细胞位置:
Cell membrane
Single-pass type II membrane protein
Colocalized with HCST on the cell surface.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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