Mouse Oas1a/ 2'-5'-oligoadenylate synthase 1A CLIA Kit

货号:

U0330m

商标:

EIAab^®

监管等级:

RUO

别名:

p42 OAS, (2-5')oligo(A) synthase 1A, Oias1

检测方法:

CLIA

特异性:

Natural and recombinant mouse 2'-5'-oligoadenylate synthase 1A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Oas1a CLIA Kit

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通用注释

亚单元:

Monomer. Homotetramer.

功能:

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

亚细胞位置:

Cytoplasm Mitochondrion Nucleus Microsome Endoplasmic reticulum Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

数据库链接

UniGene:

Mm.14301

SMR:

P11928

STRING:

10090.ENSMUSP00000079198

KEGG:

mmu:246730

Pfam:

PF01909

Uniprot: