OGT (基因名), UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (蛋白名), ogt1_human.
产品名称:
Human OGT/ UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit CLIA Kit
货号:
U13366h
商标:
EIAab®
监管等级:
别名:
O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, OGT
检测方法:
CLIA
特异性:
Natural and recombinant human UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Heterotrimer; consists of one 78 kDa subunit and two 110 kDa subunits dimerized via TPR repeats 6 and 7. Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, HCFC1, PPP1CC and ACTB. Component of a THAP1/THAP3-HCFC1-OGT complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase. Interacts (via TPR 5-6) with TET1, TET2 and TET3. Interacts with ARNTL/BMAL1.
功能:
Isoform 2: the mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line.
亚细胞位置:
Isoform 4
Cytoplasm
Nucleus
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