Human YOD1/ Ubiquitin thioesterase OTU1 CLIA Kit

货号:

U16078h

商标:

EIAab^®

监管等级:

RUO

别名:

DUBA-8, HIV-1-induced protease 7, OTU domain-containing protein 2, HIN-7, PRO0907, DUBA8, HIN7, OTUD2

检测方法:

CLIA

特异性:

Natural and recombinant human Ubiquitin thioesterase OTU1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cell Biology

规格 & 价格:

关注

Human YOD1 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Interacts with VCP; the interaction is direct. Interacts with FAF2/UBXD8. Interacts with DERL1; however interaction is dependent on the UBAX-like region, suggesting that it may be indirect.

功能:

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.

亚细胞位置:

N/A

数据库链接

UniGene:

Hs.567533

SMR:

Q5VVQ6

STRING:

9606.ENSP00000326813

KEGG:

hsa:55432

MIM: