Human ADIPOR1/ Adiponectin receptor protein 1 CLIA Kit
脂联素受体蛋白1

货号:

U2221h

商标:

EIAab^®

监管等级:

RUO

别名:

Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I, CGI-45, PAQR1, TESBP1A

检测方法:

CLIA

特异性:

Natural and recombinant human Adiponectin receptor protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human ADIPOR1 CLIA Kit

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通用注释

亚单元:

May form homooligomers and heterooligomers with ADIPOR2 (PubMed:12802337). Interacts with APPL2 (via BAR domain); hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1. Interacts with APPL1; ADIPOQ enhances this interaction; inhibites adiponectin-stimulated binding of APPL2 to ADIPOR1 (By similarity).

功能:

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

亚细胞位置:

Cell membrane Multi-pass membrane protein Localized to the cell membrane and intracellular organelles.

数据库链接

UniGene:

Hs.5298

SMR:

Q96A54

STRING:

9606.ENSP00000341785

KEGG:

hsa:51094

MIM: