Rat Pdgfc/ Platelet-derived growth factor C CLIA Kit
血小板衍生生长因子C

货号:

U0528r

商标:

EIAab^®

监管等级:

RUO

别名:

Fallotein, Spinal cord-derived growth factor, VEGF-E, rScdfg, PDGF-C, Scdgf

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant rat Platelet-derived growth factor C

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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产品说明书

说明书:

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通用注释

亚单元:

Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain).

功能:

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

亚细胞位置:

Cytoplasm Cytosol Secreted Nucleus Cytoplasmic granule Cell membrane Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets.

数据库链接

UniGene:

Rn.211987

SMR:

Q9EQX6

STRING:

10116.ENSRNOP00000015081

KEGG:

rno:79429

Pfam:

PF00431

Uniprot: