Pig Jup/ Junction plakoglobin CLIA Kit
链接斑珠蛋白

货号:

U15107p

商标:

EIAab^®

监管等级:

RUO

检测方法:

CLIA

实验类型:

Sandwich

特异性:

Natural and recombinant pig Junction plakoglobin

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Pig Jup CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
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通用注释

亚单元:

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2.

功能:

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

亚细胞位置:

Cell junction Adherens junction Cell junction Desmosome Cytoplasm Cytoskeleton Membrane Peripheral membrane protein Cytoplasmic in a soluble and membrane-associated form.

数据库链接

UniGene:

Ssc.42011

SMR:

Q8WNW3

STRING:

9823.ENSSSCP00000018469

KEGG:

ssc:397592

Pfam:

PF00514

Uniprot: