QKI (基因名), Protein quaking (蛋白名), qki_pig.
通用注释
亚单元:
Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
功能:
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
亚细胞位置:
Nucleus
Cytoplasm
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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