Rab12 (基因名), Ras-related protein Rab-12 (蛋白名), rab12_rat.
通用注释
亚单元:
Interacts with RABIF and OPTN.
功能:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
亚细胞位置:
Recycling endosome membrane
Lipid-anchor
Cytoplasmic side
Lysosome membrane
Lipid-anchor
Cytoplasmic side
Golgi apparatus membrane
Cytoplasmic vesicle
Autophagosome
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