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AGER (基因名), Advanced glycosylation end product-specific receptor (蛋白名), rage_human.

产品名称:

Human AGER/ Advanced glycosylation end product-specific receptor CLIA Kit
晚期糖基化终末产物受体

货号:

U1956h

商标:

EIAab^®

监管等级:

RUO

别名:

Receptor for advanced glycosylation end products, RAGE

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.78-50pg/mL

特异性:

Natural and recombinant human Advanced glycosylation end product-specific receptor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
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序列 / 3D
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通用注释

亚单元:

Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

功能:

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

亚细胞位置:

Isoform 10 Cell membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.534342

SMR:

Q15109

STRING:

9606.ENSP00000364217

KEGG:

hsa:177

MIM: