Human ADARB1/ Double-stranded RNA-specific editase 1 CLIA Kit
双链rna特异性编辑酶

货号:

U14672h

商标:

EIAab^®

监管等级:

RUO

别名:

RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase, ADAR2, DRADA2, RED1

检测方法:

CLIA

特异性:

Natural and recombinant human Double-stranded RNA-specific editase 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human ADARB1 CLIA Kit

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通用注释

亚单元:

Homodimer. Homodimerization is essential for its catalytic activity. Can form heterodimers with isoform 5 of ADAR/ADAR1.

功能:

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.

亚细胞位置:

Nucleus Nucleus Nucleolus Shuttles between nucleoli and the nucleoplasm.

数据库链接

UniGene:

Hs.474018

SMR:

P78563

STRING:

9606.ENSP00000353920

KEGG:

hsa:104

MIM: