S100A12 (基因名), Protein S100-A12 (蛋白名), s10ac_pig.
产品名称:
Pig S100A12/ Protein S100-A12 CLIA Kit
蛋白S100-A12
货号:
U1504p
商标:
EIAab®
监管等级:
别名:
Calgranulin-C, Extracellular newly identified RAGE-binding protein, S100 calcium-binding protein A12, CAGC, EN-RAGE
检测方法:
CLIA
特异性:
Natural and recombinant pig Protein S100-A12
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Homodimer. Homooligomer (tetramer or hexamer) in the presence of calcium, zinc and copper ions. Interacts with AGER and both calcium and zinc are essential for the interaction (By similarity). Interacts with CACYBP in a calcium-dependent manner.
功能:
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites.
亚细胞位置:
Secreted
Cytoplasm
Cytoplasm
Cytoskeleton
Cell membrane
Peripheral membrane protein
Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway (By similarity).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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