Rat S1pr1/ Sphingosine 1-phosphate receptor 1 CLIA Kit
鞘氨醇激酶受体1

货号:

U1433r

商标:

EIAab^®

监管等级:

RUO

别名:

Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, CD363, S1P receptor 1, Edg1

检测方法:

CLIA

特异性:

Natural and recombinant rat Sphingosine 1-phosphate receptor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat S1pr1 CLIA Kit

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通用注释

亚单元:

Interacts with GNAI1 and GNAI3.

功能:

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

亚细胞位置:

Cell membrane Multi-pass membrane protein Endosome Membrane raft Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization (By similarity).

数据库链接

UniGene:

Rn.109455

SMR:

P48303

STRING:

10116.ENSRNOP00000052627

KEGG:

rno:29733

Pfam:

PF00001

Uniprot: