Rat Slc27a1/ Long-chain fatty acid transport protein 1 CLIA Kit
长链脂肪酸转运蛋白1

货号:

U12692r

商标:

EIAab^®

监管等级:

RUO

别名:

Fatty acid transport protein, Solute carrier family 27 member 1, FATP-1, Fatp, Fatp1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant rat Long-chain fatty acid transport protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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说明书:

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通用注释

亚单元:

Self-associates. May function as a homodimer. Interacts with EPRS; mediates the translocation of SLC27A1 from the cytoplasm to the plasma membrane thereby increasing the uptake of long-chain fatty acids.

功能:

Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism.

亚细胞位置:

Cell membrane Single-pass membrane protein Endomembrane system Single-pass membrane protein Cytoplasm Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS. Predominantly cytoplasmic in myocytes.

数据库链接

UniGene:

Rn.1047

SMR:

P97849

STRING:

10116.ENSRNOP00000024659

Pfam:

PF00501

Uniprot:

P97849

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