Sarm1 (基因名), Sterile alpha and TIR motif-containing protein 1 (蛋白名), sarm1_mouse.
产品名称:
Mouse Sarm1/ Sterile alpha and TIR motif-containing protein 1 CLIA Kit
货号:
U15733m
商标:
EIAab®
监管等级:
别名:
Tir-1 homolog, MyD88-5, Kiaa0524
检测方法:
CLIA
特异性:
Natural and recombinant mouse Sterile alpha and TIR motif-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function (By similarity). Interacts with SDC2 (via cytoplasmic domain) and MAPK10/JNK3.
功能:
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. Can restrict West Nile virus (WNV) pathogenesis.
亚细胞位置:
Cytoplasm
Cell projection
Axon
Cell projection
Dendrite
Cell junction
Synapse
Mitochondrion
Associated with microtubules.
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