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Sart3 (基因名), Squamous cell carcinoma antigen recognized by T-cells 3 (蛋白名), sart3_mouse.

产品名称:

Mouse Sart3/ Squamous cell carcinoma antigen recognized by T-cells 3 CLIA Kit

货号:

U16153m

商标:

EIAab^®

监管等级:

RUO

别名:

Tumor-rejection antigen SART3, SART-3, Kiaa0156

检测方法:

CLIA

特异性:

Natural and recombinant mouse Squamous cell carcinoma antigen recognized by T-cells 3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Epigenetics

规格 & 价格:

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通用注释

亚单元:

Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with AGO1 and AGO2. Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3. Interacts with USP15; the interaction is direct.

功能:

U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (PubMed:21447833).

亚细胞位置:

Nucleus Nucleoplasm Nucleus Cajal body Nucleus speckle Cytoplasm

数据库链接

UniGene:

Mm.29594

SMR:

Q9JLI8

STRING:

10090.ENSMUSP00000019118

KEGG:

mmu:53890

Pfam: