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SCAP (基因名), Sterol regulatory element-binding protein cleavage-activating protein (蛋白名), scap_pig.

产品名称:

Pig SCAP/ Sterol regulatory element-binding protein cleavage-activating protein CLIA Kit
固醇调节元件结合蛋白，裂解激活蛋白

货号:

U15518p

商标:

EIAab^®

监管等级:

RUO

别名:

SCAP

检测方法:

CLIA

特异性:

Natural and recombinant pig Sterol regulatory element-binding protein cleavage-activating protein

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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通用注释

亚单元:

Membrane region forms a homotetramer. Forms a stable complex with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain. Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations. Interacts with the SEC23/SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop. Binds cholesterol through its SSC domain. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex.

功能:

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.

亚细胞位置:

Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Cytoplasmic vesicle COPII-coated vesicle membrane Multi-pass membrane protein Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.

数据库链接

UniGene:

Ssc.4111

STRING:

9823.ENSSSCP00000026028

KEGG:

ssc:494015

Pfam:

PF12349

Uniprot:

Q5MNU5

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