Human SESN1/ Sestrin-1 CLIA Kit
sestrin-1

货号:

U0440h

商标:

EIAab^®

监管等级:

RUO

别名:

p53-regulated protein PA26, PA26, SEST1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

78-5000pg/mL

特异性:

Natural and recombinant human Sestrin-1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human SESN1 CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

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通用注释

亚单元:

Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by leucine (PubMed:25263562, PubMed:26449471). Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them (PubMed:25259925). Interacts with KEAP1, RBX1 and SQSTM1; in the SQSTM1-dependent autophagic degradation of KEAP1 (PubMed:23274085). May interact with PRDX1 (PubMed:15105503).

功能:

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed.

亚细胞位置:

Nucleus Cytoplasm

数据库链接

UniGene:

Hs.591336

SMR:

Q9Y6P5

STRING:

9606.ENSP00000393762

KEGG:

hsa:27244

MIM: