TNFRSF1A (基因名), Tumor necrosis factor receptor superfamily member 1A (蛋白名), tnr1a_bovin.
产品名称:
Bovine TNFRSF1A/ Tumor necrosis factor receptor superfamily member 1A CLIA Kit
肿瘤坏死因子受体超家族成员1A
货号:
U0131b
商标:
EIAab®
监管等级:
别名:
Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, p55, p60, TNF-R1, TNF-RI, CD120a, TNFR1
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
7.8-500pg/mL
特异性:
Natural and recombinant bovine Tumor necrosis factor receptor superfamily member 1A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Neurosciences
通用注释
亚单元:
Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway.
功能:
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Golgi apparatus membrane
Single-pass type I membrane protein
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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