FAS (基因名), Tumor necrosis factor receptor superfamily member 6 (蛋白名), tnr6_pig.
产品名称:
Pig FAS/ Tumor necrosis factor receptor superfamily member 6 CLIA Kit
肿瘤坏死因子受体超家族成员6
货号:
U0030p
商标:
EIAab®
监管等级:
别名:
Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, APT1, TNFRSF6
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
6-375pg/mL
特异性:
Natural and recombinant pig Tumor necrosis factor receptor superfamily member 6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Neurosciences
通用注释
亚单元:
Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with CALM.
功能:
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
亚细胞位置:
Membrane
Single-pass type I membrane protein
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
[1].
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