Uba1 (基因名), Ubiquitin-like modifier-activating enzyme 1 (蛋白名), uba1_rat.
产品名称:
Rat Uba1/ Ubiquitin-like modifier-activating enzyme 1 CLIA Kit
类泛素修饰剂激活酶
货号:
U12404r
商标:
EIAab®
监管等级:
别名:
Ubiquitin-activating enzyme E1, Ube1
检测方法:
CLIA
特异性:
Natural and recombinant rat Ubiquitin-like modifier-activating enzyme 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Monomer. Interacts with GAN (via BTB domain).
功能:
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
亚细胞位置:
Cytoplasm
Mitochondrion
Nucleus
数据库链接
验证序列:
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