Mouse Uba3/ NEDD8-activating enzyme E1 catalytic subunit CLIA Kit
nedd8活化酶E1催化亚基

货号:

U1027m

商标:

EIAab^®

监管等级:

RUO

别名:

NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, Ube1c

检测方法:

CLIA

特异性:

Natural and recombinant mouse NEDD8-activating enzyme E1 catalytic subunit

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Mouse Uba3 CLIA Kit

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通用注释

亚单元:

Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand (By similarity). Interacts with TBATA.

功能:

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

亚细胞位置:

N/A

数据库链接

UniGene:

Mm.277626

SMR:

Q8C878

STRING:

10090.ENSMUSP00000086701

KEGG:

mmu:22200

Pfam: