Rat Ube2i/ SUMO-conjugating enzyme UBC9 CLIA Kit
SUMO-硫酸盐结合酶UBC9

货号:

U11134r

商标:

EIAab^®

监管等级:

RUO

别名:

RING-type E3 SUMO transferase UBC9, SUMO-protein ligase, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-conjugating enzyme UbcE2A, Ubiquitin-protein ligase I, Ubce9

检测方法:

CLIA

特异性:

Natural and recombinant rat SUMO-conjugating enzyme UBC9

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Epigenetics

规格 & 价格:

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Rat Ube2i CLIA Kit

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通用注释

亚单元:

Interacts with RASD2 (PubMed:19498170). Interacts with TCF3 (PubMed:9013644). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1, PARP, HIPK1, HIPK2 and PPM1J. Interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts with FOXL. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts with DNM1l; the interaction Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain. Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains. Interacts with FHIT. Interacts with PRKRA and p53/TP53. Interacts with UHRF2. Interacts with NR3C1 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1. Interacts with ZNF451. Identified in a complex with SUMO2 and UBC9, where one ZNF451 interacts with one UBC9 and two SUMO2 chains, one bound to the UBC9 active site and the other to another region of the same UBC9 molecule. Interacts with SETX (By similarity). Interacts with CPEB3.

功能:

Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386'.

亚细胞位置:

Nucleus Cytoplasm Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity).

数据库链接

UniGene:

Rn.2274

SMR:

P63281

STRING:

10116.ENSRNOP00000024406

KEGG:

rno:25573

Pfam: