Ube2b (基因名), Ubiquitin-conjugating enzyme E2 B (蛋白名), ube2b_mouse.
产品名称:
Mouse Ube2b/ Ubiquitin-conjugating enzyme E2 B CLIA Kit
泛素结合酶E2 B
货号:
U1063m
商标:
EIAab®
监管等级:
别名:
E2 ubiquitin-conjugating enzyme B, E214K, RAD6 homolog B, Ubiquitin carrier protein B, Ubiquitin-protein ligase B, HR6B, Rad6b
检测方法:
CLIA
特异性:
Natural and recombinant mouse Ubiquitin-conjugating enzyme E2 B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with RAD18, UBR2 and WAC.
功能:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
亚细胞位置:
Cell membrane
Nucleus
In peripheral neurons, expressed both at the plasma membrane and in nuclei.
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