USP37 (基因名), Ubiquitin carboxyl-terminal hydrolase 37 (蛋白名), ubp37_pig.
产品名称:
Pig USP37/ Ubiquitin carboxyl-terminal hydrolase 37 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37
检测方法:
CLIA
特异性:
Natural and recombinant pig Ubiquitin carboxyl-terminal hydrolase 37
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with FZR1/CDH1. Interacts with CDT1.
功能:
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
亚细胞位置:
N/A
验证序列:
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