Ubqln4 (基因名), Ubiquilin-4 (蛋白名), ubql4_mouse.
产品名称:
Mouse Ubqln4/ Ubiquilin-4 CLIA Kit
Ubiquilin-4
货号:
U12975m
商标:
EIAab®
监管等级:
别名:
Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, Connexin43-interacting protein of 75 kDa, A1Up, CIP75, Cip75, Ubin
检测方法:
CLIA
特异性:
Natural and recombinant mouse Ubiquilin-4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Homooligomer. Binds ATXN1/SCA1. Interaction with ATXN1 inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding (By similarity). Interacts (via ubiquitin-like domain) with PSMD2 and PSMD4, regulatory subunits of the proteasome (PubMed:18079109). Binds signal sequences of proteins that are targeted to the endoplasmic reticulum (PubMed:11162551). Interacts (via UBA domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site (PubMed:18079109, PubMed:20940304, PubMed:20127391). Interacts (via UBA domain) with polyubiquitin chains and polyubiquitinated proteins (PubMed:20940304). Interacts with HERPUD1. Interacts (via ubiquitin-like domain) with UBQLN1 (via UBA domain). Interacts (via STI1 1 and 2 domains) with MAP1LC3A/B/C. Interacts with UBQLN2.
功能:
Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (PubMed:18079109, PubMed:20940304). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion.
亚细胞位置:
Nucleus
Cytoplasm
Endoplasmic reticulum
Cytoplasm
Perinuclear region
Cytoplasmic vesicle
Autophagosome
Colocalizes with the proteasome, both in nucleus and cytoplasm (By similarity).
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