UBR2 (基因名), E3 ubiquitin-protein ligase UBR2 (蛋白名), ubr2_human.
产品名称:
Human UBR2/ E3 ubiquitin-protein ligase UBR2 CLIA Kit
货号:
U2363h
商标:
EIAab®
监管等级:
别名:
N-recognin-2, RING-type E3 ubiquitin transferase UBR2, Ubiquitin-protein ligase E3-alpha-2, Ubiquitin-protein ligase E3-alpha-II, C6orf133, KIAA0349
检测方法:
CLIA
特异性:
Natural and recombinant human E3 ubiquitin-protein ligase UBR2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with UBE2B; promotes the UBE2B-H2A interaction and the ubiquitination of histone H2A by UBE2B and UBR2 (By similarity). Interacts with RECQL4.
功能:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
亚细胞位置:
Nucleus
Associated with chromatin during meiosis.
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