Pig UCHL3/ Ubiquitin carboxyl-terminal hydrolase isozyme L3 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Ubiquitin thioesterase L3, UCH-L3

检测方法:

CLIA

特异性:

Natural and recombinant pig Ubiquitin carboxyl-terminal hydrolase isozyme L3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Pig UCHL3 CLIA Kit

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通用注释

亚单元:

Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates.

功能:

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3, and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Ssc.13668

SMR:

Q06AB3

STRING:

9823.ENSSSCP00000010107

KEGG:

ssc:768115

Pfam: