UGT1A1 (基因名), UDP-glucuronosyltransferase 1-1 (蛋白名), ud11_human.
产品名称:
Human UGT1A1/ UDP-glucuronosyltransferase 1-1 CLIA Kit
UDP葡糖醛酸基转移酶1-1
货号:
U12952h
商标:
EIAab®
监管等级:
别名:
Bilirubin-specific UDPGT isozyme 1, UDP-glucuronosyltransferase 1-A, UDP-glucuronosyltransferase 1A1, hUG-BR1, UGT-1A, UDPGT 1-1, GNT1, UGT1
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
19.5-1250pg/mL
特异性:
Natural and recombinant human UDP-glucuronosyltransferase 1-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
功能:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
亚细胞位置:
Isoform 2
Microsome
Endoplasmic reticulum
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