Pig UIMC1/ BRCA1-A complex subunit RAP80 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Receptor-associated protein 80, Ubiquitin interaction motif-containing protein 1, RAP80

检测方法:

CLIA

特异性:

Natural and recombinant pig BRCA1-A complex subunit RAP80

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Pig UIMC1 CLIA Kit

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通用注释

亚单元:

Interacts with TSP57 (By similarity). Component of the ARISC complex, at least composed of UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1, NR6A1 and UBE2I.

功能:

Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

亚细胞位置:

Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).

数据库链接

UniGene:

Ssc.5212

SMR:

A0P8Z5

STRING:

9823.ENSSSCP00000026135

KEGG:

ssc:100037949

Uniprot: