Rat Nae1/ NEDD8-activating enzyme E1 regulatory subunit CLIA Kit

货号:

U16099r

商标:

EIAab^®

监管等级:

RUO

别名:

Amyloid beta precursor protein-binding protein 1, 59 kDa, Amyloid protein-binding protein 1, APP-BP1, Appbp1

检测方法:

CLIA

特异性:

Natural and recombinant rat NEDD8-activating enzyme E1 regulatory subunit

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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Rat Nae1 CLIA Kit

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通用注释

亚单元:

Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2.

功能:

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

亚细胞位置:

Cell membrane Colocalizes with APP in lipid rafts.

数据库链接

UniGene:

Rn.4279

SMR:

Q9Z1A5

STRING:

10116.ENSRNOP00000045593

Pfam:

PF00899

Uniprot: