Vangl2 (基因名), Vang-like protein 2 (蛋白名), vang2_mouse.
产品名称:
Mouse Vangl2/ Vang-like protein 2 CLIA Kit
Vang样蛋白2
货号:
U15196m
商标:
EIAab®
监管等级:
别名:
Loop-tail protein 1, Loop-tail-associated protein, Van Gogh-like protein 2, Lpp1, Ltap
检测方法:
CLIA
特异性:
Natural and recombinant mouse Vang-like protein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homodimer and heterodimer with Vangl1. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Variants Glu-255 and Asn-464 impair interaction with the DVL proteins. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3.
功能:
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (PubMed:16495441).
亚细胞位置:
Cell membrane
Multi-pass membrane protein
数据库链接
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