VHL (基因名), Von Hippel-Lindau disease tumor suppressor (蛋白名), vhl_canlf.
产品名称:
Dog VHL/ Von Hippel-Lindau disease tumor suppressor CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
pVHL
检测方法:
CLIA
特异性:
Natural and recombinant dog Von Hippel-Lindau disease tumor suppressor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Part of a complex with Elongin BC complex and hydroxylated HIF1A. Interacts with CUL2. Part of multisubunit CBC(VHL) E3 ubiquitin ligase complexes with Elongin BC complex, CUL2 or CUL5 and RBX1. Interacts with HIF1AN. Part of a complex with HIF1A, HIF1AN and HDAC1 or HDAC2 or HDAC3. The C-terminus interacts with VBP1. Interacts with RNF139 and UBP33. Interacts with JADE1 (By similarity). Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2. Interacts with LIMD1 (via LIM zinc-binding 2). Interacts with AJUBA (via LIM domains) and WTIP (via LIM domains) (By similarity). Interacts with EPAS1. Interacts with CARD9.
功能:
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.
亚细胞位置:
Cytoplasm
Membrane
Peripheral membrane protein
Nucleus
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