VPS52 (基因名), Vacuolar protein sorting-associated protein 52 homolog (蛋白名), vps52_canlf.
产品名称:
Dog VPS52/ Vacuolar protein sorting-associated protein 52 homolog CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
检测方法:
CLIA
特异性:
Natural and recombinant dog Vacuolar protein sorting-associated protein 52 homolog
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin. Interacts with RAB6A and STX10.
功能:
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
亚细胞位置:
Golgi apparatus
Trans-Golgi network membrane
Peripheral membrane protein
Endosome membrane
Peripheral membrane protein
Recycling endosome
Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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