Rat Wasf1/ Wiskott-Aldrich syndrome protein family member 1 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Protein WAVE-1, WASP family protein member 1, Wave1

检测方法:

CLIA

特异性:

Natural and recombinant rat Wiskott-Aldrich syndrome protein family member 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

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Rat Wasf1 CLIA Kit

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通用注释

亚单元:

Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex. Interacts with ABI1 (via N-terminus). Interacts with SORBS2; this interaction greatly enhances phosphorylation by ABL1 and dephosphorylation by PTPN12 and might mediate partial to focal adhesion sites.

功能:

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.

亚细胞位置:

Cytoplasm Cytoskeleton Cell junction Synapse Cell junction Focal adhesion Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2. In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity).

数据库链接

UniGene:

Rn.7692

SMR:

Q5BJU7

STRING:

10116.ENSRNOP00000064342

KEGG:

rno:294568

Pfam:

PF02205

Uniprot: